Warn: Go to bed early early right daily life a kind of morbid state

Warn: Go to bed early early right daily life a kind of morbid state



The biological clock is a kind of innate tools of ours, it can keep us basically regarding 24 hours as behavioral cycle, sleep and have a meal in the regular time interval, but it may offset. Even go to bed early and get up early in the way of working and resting of such generally acknowledged health, it may be a kind of disease.
The scientist calls that the family period leading syndrome (FASPS) of sleep ,The time that the person who suffers from such rare disease goes to bed and gets up is earlier by four hours than other people.
It is perhaps a good recipe of a healthy life to go to bed early and get up early, but to some persons liking getting up early, this may be the state that a misfortune is written into the gene. These people suffer from the family period leading syndrome (FASPS) of sleep ,The time that the person who suffers from such rare disease goes to bed and gets up is earlier by four hours than other people. Study the intersection of person and the intersection of skin and one under cell that train already variation that confirm after the behavior of albumen, a kind of simple protein that the researcher claimed the origin of this syndrome may be the nucleus is exported.
The biological clock is a kind of innate tools of ours, it can keep us basically regarding 24 hours as behavioral cycle, sleep and have a meal in the regular time interval, but it may offset. Discover a lot of patients who suffer from FASPS are called the protein of PERIOD2 and made a variation. Achim Kramer of Berlin Charit Universit tsmedizin says, someone thinks the albumen effect of this kind of variation comes from the disappearance that a kind of main phosphate forms a cluster, but unable to confirm its mechanism.
It is generally acknowledged, decorate phosphoric acid of protein of PERIOD2 family the less the more stable it is, but Kramer and colleague find the situation is just opposite in this disease.
Their work on Genes and Development finds, the speed that this mutant protein degrades is more than twice of the normal speed, very obvious this results from transporting to from the nucleus fast the thick liquid of afterbirth from it, this kind of phenomenon is very general in enzyme which digests the albumen. Kramer explains: "Usually, this kind of protein evolves from the thick liquid of afterbirth, then enter core and inhibit one's own formation. "
When it is pumped the core, this inhibitory activity will be weakened. The nuclear speed happens and change quickly in protein to make a variation, so inhibitory activity is just earlier neutralization, this has produced a circulation accelerating. Kramer claims: "These are the first human behavior that can be really explained at the albumen level. "
Other people think this result is a beneficial progress. The sleep geneticist Louis tacek of University of California of San Francisco says, this result can help us to understand " the accurate biological clock is how to be revised " . He add animal experiment can let the intersection of we and fine the intersection of research and different phosphate form a cluster, apply to living protein of organism what kind of contribution does it have.
|