Watch out for the genuine erythrocyte increase disease

Watch out for the genuine erythrocyte increase disease
Refined hospital professor of Hunan of middle and southern university Luo XueHong
The erythrocyte increases disease is commonly called as many blood diseases, it is a kind of chronic bone marrow because the unusual multi-functional stem cell cloned hyperplasia that increases natural disposition disease, rely mainly on the fact that the erythrocyte increases, increase with the leucocyte, blood platelet. Morbidity about 1/ 10 Wan, take place more about 60 years old old person, men exceed women.
The disease is slow that this disease gets up, can just symptom appears after pathological change several years, some are even found while checking the blood accidentally. It is early can present headache, dizzy, tired, tinnitus, having dim eyesight, forgetful, etc. There are end numbness of limb and shouting pain, many sweat, eyesight obstacle, skin pruritus and peptic ulcer and symptom later, the patient can have inclination of bleeding. About half the a case has hypertension. While increasing with the blood platelet, there can be thrombosis, infarction or phlebitis. Purpureal without being shown with skin and mucous membrane in patient,particularly by cheek, lip, tongue, ear, nose, shank and terminal upper limbses (mean, toe and small fish borders great) It is very. The conjunctiva of eyes shows congestion. Most patients, with liver splenomegaly.
The patient scarcely needs to treat, the person who has slight symptom can be dealt with to the ill. Act as apparent to increase erythrocyte only ' Such as the blood cell specific volume> 0.6)And may take place at the time of thrombus or other complications the side consider treating. Treatment is to make the blood capacity and capacity of erythrocyte close normally as soon as possible, inhibit hematopoietic function of the bone marrow, thus relieve the condition.
Intravenous bloodletting: Begin to bleed 300~500ml time, press the erythrocyte, accumulate, drop to 45%, bleeds for 3~4 times every year according to the situation every 2~3 days, keep the erythrocyte pressing, accumulating in under 45%.
Chemotherapy: Urea 0.5~1.5g of hydroxyl per day, take orally. Can would rather can use the intersection of Mary and blue or tumour 4~6mg per day have the intersection of hydroxyl and urine, take orally; Keep the erythrocyte, accumulate, drop to 50% o'clock decrement keeps or stops medicines. Three sharp China fir ester alkali 1~2mg per day, the vein is instilled, it is a course of treatment in 10 days to use together.
Isotope 32P: 3~5mCi intravenous injection, or 2~4mCi takes orally, once week, spends twice. Repeatable after 4 months, the dosage is reduced according to the circumstances. Suitable for the old patient over 65.
Interferon: 3MU/d, skin note, press the erythrocyte, accumulate, drop to 45%, change into for 2~3 times keep treating in week, gt of course of treatment; 6 months. Can make the blood platelet count and reduce, skin pruritus and splenomegaly can also be got and shown improvement.
Typical case:
Patient, male, 52 years old, because a red, liver splenomegaly comes to go to a doctor. Questioned the medical history, repeated giddy, companion left lower extremities activity obstacle uncomfortable in chest, were once diagnosed as essential hypertension, brain infarction by one institute 5 years ago. Medical history of deny liver trematodiasis, hepatitis, is addicted to drinking etc..
Check the body: Blood pressure 170/100mmHg, one is red, presents the drunk looks, the pupil was waited for big etc. round, lip cyanosis, the neck has not been resisted, the auscultation of heart and lungs is not unusual. The belly is flat and soft, the left rib lower 6cm of spleen, a pair of lower extremities have no edema, the muscular strength of left lower extremities is reduced. The head CT shows the brain stem of basal festival of right. Blood routine: Hemoglobin 197g/L, the erythrocyte 610* 1012 L, the blood platelet 320* 109 L, the leucocyte 40* 109 L, the neutral cells 0.76, the lymphocyte 0.02. The bone marrow is alike: The bone marrow is each that hyperplasia is extremely active. Diagnose as the genuine erythrocyte increase disease.
|